This work is licensed under a Creative Commons Attribution 4.0 International License.
L1
General Information
DRACP ID DRACP02823
Peptide Name L1
Sequence KKK
Sequence Length 3
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Lipopeptides Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=3.9 ± 1.1 μg/mL | MTS assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes:HC50=90.0 ± 6.5 µg/ml
Normal (non-cancerous) Cytotoxicity HaCat: IC50=5.2 ± 0.6 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification CH3(CH2)14CO, Palmitic acid
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C18H38N6O4
Absent amino acids ACDEFGHILMNPQRSTVWY
Common amino acids K
Mass 43839
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 0
Net charge 3
Boman Index -1665
Hydrophobicity -390
Aliphatic Index 0
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33003569
Title Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.