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PuroA
General Information
DRACP ID DRACP02829
Peptide Name PuroA
Sequence FPVTWRWWKWWKG
Sequence Length 13
UniProt ID P33432
PubChem CID Not available
Origin Synthetic (Based Puroindoline-A)
Type Synthetic peptide
Classification
Active ACP Membrane lysis Binding intracellular targets
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>250 μg/mL | MTT assay | 24 h | 1 |
Hemolytic Activity Sheep erythrocytes: No hemolysis up tp 500 µg/ml
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=250 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C98H123N23O15
Absent amino acids ACDEHILMNQSY
Common amino acids W
Mass 207741
Pl 11.82
Basic residues 3
Acidic residues 0
Hydrophobic residues 7
Net charge 3
Boman Index -898
Hydrophobicity -96.15
Aliphatic Index 22.31
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 27500
Absorbance 280nm 2291.67
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33207639
Title Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.