TRPs dW7

General Information


DRACP ID  DRACP02838

Peptide Name   TRPs dW7

Sequence  WrWwkWW

Sequence Length  7

UniProt ID  P33432 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane lysis Binding intracellular targets



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=125 μg/mL MTT assay 24 h 1

Hemolytic Activity  Sheep erythrocytes: No hemolysis up tp 500 µg/ml

Normal (non-cancerous) Cytotoxicity  NIH 3T3: IC50>250 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Dual mechanism, with the disruption of the membrane integrity possibly being the main cause of cell death, but only after peptide translocation and binding to intracellular targets.

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  r=D-Arg; w=D-Trp

Chiral  Mix



Physicochemical Information


Formula  C44H36N8O2

Absent amino acids  ACDEFGHIKLMNPQRSTVY

Common amino acids  W

Mass  81602

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  4

Net charge  0

Boman Index  932

Hydrophobicity  -51.43

Aliphatic Index  0

Half Life 
  /

Extinction Coefficient cystines  22000

Absorbance 280nm  3666.67

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33207639

Title  Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells

Doi 10.3390/ijms21228624

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_16989

DRACP is developed by Dr.Zheng's team.