Peptide Libraray

TRPs dWW

General Information

DRACP ID DRACP02841

Peptide Name TRPs dWW

Sequence WWrWwkWW

Sequence Length 8

UniProt ID P33432

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP Membrane lysis Binding intracellular targets

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50=125 μg/mL	MTT assay	24 h	1

Hemolytic Activity Sheep erythrocytes: No hemolysis up tp 500 µg/ml

Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=250 µg/ml

Target Not available

Affinity Not available

Mechanism Dual mechanism, with the disruption of the membrane integrity possibly being the main cause of cell death, but only after peptide translocation and binding to intracellular targets.

Nature Anticancer; Antibacterial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification r=D-Arg; w=D-Trp

Chiral Mix

Physicochemical Information

Formula C55H46N10O3

Absent amino acids ACDEFGHIKLMNPQRSTVY

Common amino acids W

Mass 102007

Pl 6.11

Basic residues 0

Acidic residues 0

Hydrophobic residues 5

Net charge 0

Boman Index 1165

Hydrophobicity -56.25

Aliphatic Index 0

Half Life
/

Extinction Coefficient cystines 27500

Absorbance 280nm 3928.57

Polar residues 0

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33207639

Title Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells

Doi 10.3390/ijms21228624

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_16992