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LHH1
General Information
DRACP ID DRACP02842
Peptide Name LHH1
Sequence AFALIAGALYRIFHRR
Sequence Length 16
UniProt ID Q036I7
PubChem CID Not available
Origin Lactobacillus casei HZ1
Type Synthetic peptide
Classification
Active ACP Membrane lysis Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HCT 116 | Colon carcinoma | Carcinoma | IC50=40.83 μM | MTT assay | 24 h | 1 |
| C666-1 | Nasopharyngeal carcinoma | Carcinoma | IC50=18.27 μM | MTT assay | 24 h | 1 |
| MGC-803 | Gastric mucinous adenocarcinoma | Carcinoma | IC50=31.55 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Goat erythrocytes: HC50=187.2 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C89H139N27O18
Absent amino acids CDEKMNPQSTVW
Common amino acids A
Mass 214300
Pl 12.2
Basic residues 4
Acidic residues 0
Hydrophobic residues 10
Net charge 4
Boman Index -1574
Hydrophobicity 68.75
Aliphatic Index 122.5
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 99.33
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33175275
Title LHH1, a novel antimicrobial peptide with anti-cancer cell activity identified from Lactobacillus casei HZ1
Doi 10.1186/s13568-020-01139-8
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_16955
This work is licensed under a Creative Commons Attribution 4.0 International License.