Arenicin-3 [Y5R,V8A,Y9S,V13L], NZ17125

General Information


DRACP ID  DRACP02849

Peptide Name   Arenicin-3 [Y5R,V8A,Y9S,V13L], NZ17125

Sequence  GFCWRVCASRNGLRVCYRRCN

Sequence Length  21

UniProt ID  A0A3F2YLM5 

PubChem CID  Not available

Origin  Synthetic (Derived from Arenicin-3)

Type  Synthetic peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma CC50=299 μg/ml Resazurin assay 24 h 1

Hemolytic Activity  Human erythrocytes: HC10= µg/ml

Normal (non-cancerous) Cytotoxicity  HEK-293: CC50=250 µg/ml; HK-2: CC50=110 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02849

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys3<--->Cys20; Cys7<--->Cys16

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C105H167N39O26S4

Absent amino acids  DEHIKMPQT

Common amino acids  R

Mass  287688

Pl  9.72

Basic residues  5

Acidic residues  0

Hydrophobic residues  6

Net charge  5

Boman Index  -6430

Hydrophobicity  -30.95

Aliphatic Index  50.95

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  7240

Absorbance 280nm  362

Polar residues  10

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 32576824

Title  An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

Doi 10.1038/s41467-020-16950-x

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_17219

DRACP is developed by Dr.Zheng's team.