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Arenicin-3 [Y5R,V6A], NZ17230
General Information
DRACP ID DRACP02856
Peptide Name Arenicin-3 [Y5R,V6A], NZ17230
Sequence GFCWRACVYRNGVRVCYRRCN
Sequence Length 21
UniProt ID A0A3F2YLM5
PubChem CID Not available
Origin Synthetic (Derived from Arenicin-3)
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | CC50>300 μg/ml | Resazurin assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC10= µg/ml
Normal (non-cancerous) Cytotoxicity HEK-293: CC50=223 µg/ml; HK-2: CC50>250 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys3<--->Cys20; Cys7<--->Cys16
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C110H169N39O26S4
Absent amino acids DEHIKLMPQST
Common amino acids R
Mass 293895
Pl 9.54
Basic residues 5
Acidic residues 0
Hydrophobic residues 6
Net charge 5
Boman Index -6192
Hydrophobicity -31.43
Aliphatic Index 46.19
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 8730
Absorbance 280nm 436.5
Polar residues 10
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32576824
Title An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
Doi 10.1038/s41467-020-16950-x
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_17226
This work is licensed under a Creative Commons Attribution 4.0 International License.