This work is licensed under a Creative Commons Attribution 4.0 International License.
Ixosin
General Information
DRACP ID DRACP02857
Peptide Name Ixosin
Sequence GLHKVMREVLGYERNSYKKFFLR
Sequence Length 23
UniProt ID Q2LKX9
PubChem CID Not available
Origin Ixodes sinensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 9% Killing=16-32 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK-293: Not active up to 32 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C132H208N38O32S
Absent amino acids ACDIPQTW
Common amino acids KLR
Mass 326397
Pl 10.71
Basic residues 7
Acidic residues 2
Hydrophobic residues 7
Net charge 5
Boman Index -5698
Hydrophobicity -68.7
Aliphatic Index 76.09
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 2980
Absorbance 280nm 135.45
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27622949
Title Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B
Doi 10.1021/acsinfecdis.5b00140
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_17324
This work is licensed under a Creative Commons Attribution 4.0 International License.