This work is licensed under a Creative Commons Attribution 4.0 International License.
Ixosin (4-23)
General Information
DRACP ID DRACP02859
Peptide Name Ixosin (4-23)
Sequence KVMREVLGYERNSYKKFFLR
Sequence Length 20
UniProt ID Q2LKX9
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 19% Killing=128 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK-293: Not active up to 128 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C118H187N33O29S
Absent amino acids ACDHIPQTW
Common amino acids KR
Mass 290310
Pl 10.71
Basic residues 6
Acidic residues 2
Hydrophobic residues 6
Net charge 4
Boman Index -5818
Hydrophobicity -80
Aliphatic Index 68
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 2980
Absorbance 280nm 156.84
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27622949
Title Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B
Doi 10.1021/acsinfecdis.5b00140
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_17324
This work is licensed under a Creative Commons Attribution 4.0 International License.