This work is licensed under a Creative Commons Attribution 4.0 International License.
Ixosin (7-18)
General Information
DRACP ID DRACP02867
Peptide Name Ixosin (7-18)
Sequence REVLGYERNSYK
Sequence Length 12
UniProt ID Q2LKX9
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 15% Killing>128 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK-293: 18% Killing>128 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C66H104N20O21
Absent amino acids ACDFHIMPQTW
Common amino acids ERY
Mass 171004
Pl 9.14
Basic residues 3
Acidic residues 2
Hydrophobic residues 2
Net charge 1
Boman Index -4943
Hydrophobicity -160
Aliphatic Index 56.67
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 2980
Absorbance 280nm 270.91
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27622949
Title Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B
Doi 10.1021/acsinfecdis.5b00140
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_17324
This work is licensed under a Creative Commons Attribution 4.0 International License.