This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37 (17-29) [K25L]
General Information
DRACP ID DRACP02870
Peptide Name LL-37 (17-29) [K25L]
Sequence FKRIVQRILDFLR
Sequence Length 13
UniProt ID P49913
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=3.9 μg/ml | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=450 µg/ml
Normal (non-cancerous) Cytotoxicity DLF lung fibroblasts: IC50=20.1 μg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C80H134N24O17
Absent amino acids ACEGHMNPSTWY
Common amino acids R
Mass 191832
Pl 12.22
Basic residues 4
Acidic residues 1
Hydrophobic residues 7
Net charge 3
Boman Index -3489
Hydrophobicity 15.38
Aliphatic Index 142.31
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32567085
Title Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents
Doi 10.1002/psc.3254
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_17789
This work is licensed under a Creative Commons Attribution 4.0 International License.