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H-14, Hymenochirin-1B [P5K, E6K, D9K]
General Information
DRACP ID DRACP02892
Peptide Name H-14, Hymenochirin-1B [P5K, E6K, D9K]
Sequence IKLSKKTKKNLKKVLKGAIKGAIAVAKMV
Sequence Length 29
UniProt ID W8PRC4
PubChem CID Not available
Origin Synthetic (Derived from Hymenochirin-1B)
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=0.98±0.11 μM | MTT assay | 96 h | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=1.841±0.34 μM | MTT assay | 96 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | IC50=4.54±0.25 μM | MTT assay | 96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C143H268N40O33S
Absent amino acids CDEFHPQRWY
Common amino acids K
Mass 360765
Pl 11.75
Basic residues 10
Acidic residues 0
Hydrophobic residues 13
Net charge 10
Boman Index -1500
Hydrophobicity 6.21
Aliphatic Index 124.48
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30789695
Title Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy
Doi 10.1021/acschembio.9b00046
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.