Peptide Libraray

H-18, Hymenochirin-1B [P5K,E6K,D9K; A18,A22 S5]

General Information

DRACP ID DRACP02896

Peptide Name H-18, Hymenochirin-1B [P5K,E6K,D9K; A18,A22 S5]

Sequence IKLSKKTKKNLKKVLKGⓍIKGⓍIAVAKMV

Sequence Length 29

UniProt ID W8PRC4

PubChem CID Not available

Origin Synthetic (Derived from Hymenochirin-1B)

Type Synthetic peptide

Classification

Active ACP Stapled Peptides

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Carcinoma	IC50=0.89±0.21 μM	MTT assay	96 h	1
HCT 116	Colon carcinoma	Carcinoma	IC50=1.11±0.21 μM	MTT assay	96 h	1
HepG2	Hepatoblastoma	Blastoma	IC50=1.61±0.21 μM	MTT assay	96 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Stapled: Ⓧ(18) and Ⓧ (22) are cross-linked by hydrocarbon stapling

N-terminal Modification Free

C-terminal Modification Free

Other Modification Ⓧ=(S)-N-Fmoc-2-(4′-pentenyl)alanine

Chiral L

Physicochemical Information

Formula C137H254N38O29S

Absent amino acids CDEFHPQRWY

Common amino acids K

Mass 364945

Pl 11.75

Basic residues 10

Acidic residues 0

Hydrophobic residues 11

Net charge 10

Boman Index -1862

Hydrophobicity -6.21

Aliphatic Index 117.59

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30789695

Title Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy

Doi 10.1021/acschembio.9b00046

Year 2019

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_18018