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H-57, Hymenochirin-1B [P5K,D9K; S4,T7,N10-GlcNAc; A18,A22 S5]
General Information
DRACP ID DRACP02900
Peptide Name H-57, Hymenochirin-1B [P5K,D9K; S4,T7,N10-GlcNAc; A18,A22 S5]
Sequence IKLXKEXKKXLKKVLKGXIKGXIAVAKMV
Sequence Length 29
UniProt ID W8PRC4
PubChem CID Not available
Origin Synthetic (Derived from Hymenochirin-1B)
Type Synthetic peptide
Classification
Active ACP Glycosylated peptide Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=1.10±0.31 μM | MTT assay | 96 h | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=1.65±0.28 μM | MTT assay | 96 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | IC50=2.71±0.05 μM | MTT assay | 96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond X18<--->X22
N-terminal Modification Free
C-terminal Modification Free
Other Modification X(4)=Ser-GlcNAc; X(7)=Thr-GlcNAc; X(10)=Asn-GlcNAc; X(18/22)=(S)-N-Fmoc-2-(4′-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C125H225N33O22S
Absent amino acids CDFHNPQRSTWY
Common amino acids K
Mass 362406
Pl 11.34
Basic residues 9
Acidic residues 1
Hydrophobic residues 11
Net charge 8
Boman Index -727
Hydrophobicity 12.41
Aliphatic Index 117.59
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30789695
Title Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy
Doi 10.1021/acschembio.9b00046
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_18022
This work is licensed under a Creative Commons Attribution 4.0 International License.