sC18 [E15F,E15F,K16F]

General Information


DRACP ID  DRACP02913

Peptide Name   sC18 [E15F,E15F,K16F]

Sequence  GLRKRLRKFFNKIKFF

Sequence Length  16

UniProt ID  P25230 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Cell-penetrating peptides Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma >80% Killing=40 µM Resazurin assay 24 h 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma 80% Killing=40 µM Resazurin assay 24 h 1

Hemolytic Activity  Human erythrocytes: <10% Hemolysis =40 µM

Normal (non-cancerous) Cytotoxicity  HEK293: 40% Killing=40 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02913

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C102H164N30O18

Absent amino acids  ACDEHMPQSTVWY

Common amino acids  FK

Mass  236633

Pl  12.83

Basic residues  7

Acidic residues  0

Hydrophobic residues  7

Net charge  7

Boman Index  -4598

Hydrophobicity  -60.63

Aliphatic Index  73.13

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33313751

Title  Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity

Doi 10.1042/BCJ20200698

Year  2021

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_18146

DRACP is developed by Dr.Zheng's team.