sC18 [E15Del]

General Information


DRACP ID  DRACP02914

Peptide Name   sC18 [E15Del]

Sequence  GLRKRLRKFRNKIKK

Sequence Length  15

UniProt ID  P25230 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Cell-penetrating peptides Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma <10% Killing=40 µM Resazurin assay 24 h 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma 35% Killing=40 µM Resazurin assay 24 h 1

Hemolytic Activity  Human erythrocytes: <10% Hemolysis =40 µM

Normal (non-cancerous) Cytotoxicity  HEK293: <10% Killing=40 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02914

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C87H161N33O17

Absent amino acids  ACDEHMPQSTVWY

Common amino acids  K

Mass  219133

Pl  13

Basic residues  9

Acidic residues  0

Hydrophobic residues  4

Net charge  9

Boman Index  -7539

Hydrophobicity  -176.67

Aliphatic Index  78

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33313751

Title  Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity

Doi 10.1042/BCJ20200698

Year  2021

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_18147

DRACP is developed by Dr.Zheng's team.