This work is licensed under a Creative Commons Attribution 4.0 International License.
sC18 [R10F,E15Del,K16F]
General Information
DRACP ID DRACP02915
Peptide Name sC18 [R10F,E15Del,K16F]
Sequence GLRKRLRKFFNKIKF
Sequence Length 15
UniProt ID P25230
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cell-penetrating peptides Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | <10% Killing=40 µM | Resazurin assay | 24 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | >90% Killing=40 µM | Resazurin assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <10% Hemolysis =40 µM
Normal (non-cancerous) Cytotoxicity HEK293: 20% Killing=40 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C93H155N29O17
Absent amino acids ACDEHMPQSTVWY
Common amino acids K
Mass 220132
Pl 12.83
Basic residues 7
Acidic residues 0
Hydrophobic residues 6
Net charge 7
Boman Index -4896
Hydrophobicity -83.33
Aliphatic Index 78
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33313751
Title Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_18148
This work is licensed under a Creative Commons Attribution 4.0 International License.