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Phakellistatin 15
General Information
DRACP ID DRACP02919
Peptide Name Phakellistatin 15
Sequence PWIPLTPL
Sequence Length 8
UniProt ID Not available
PubChem CID 46209786
Origin Phakellia fusca
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| P388 | Mouse lymphoma | Lymphoma | IC50=8.5 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Leu8
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C48H73N9O10
Absent amino acids ACDEFGHKMNQRSVY
Common amino acids P
Mass 106120
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 4
Net charge 0
Boman Index 1452
Hydrophobicity 71.25
Aliphatic Index 146.25
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 785.71
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20345147
Title Proline-containing cyclopeptides from the marine sponge Phakellia fusca
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18416
This work is licensed under a Creative Commons Attribution 4.0 International License.