This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 16
General Information
DRACP ID DRACP02920
Peptide Name Phakellistatin 16
Sequence PFDSRAVTY
Sequence Length 9
UniProt ID Not available
PubChem CID 44250811
Origin Phakellia fusca
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| P388 | Mouse lymphoma | Lymphoma | IC50=5.4 μM | MTT assay | 48 h | 1 |
| BEL-7402 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=14.3 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Tyr9
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C48H70N12O15
Absent amino acids CEGHIKLMNQW
Common amino acids ADFPRSTVY
Mass 119802
Pl 6.34
Basic residues 1
Acidic residues 1
Hydrophobic residues 3
Net charge 0
Boman Index -2092
Hydrophobicity -40
Aliphatic Index 43.33
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 1490
Absorbance 280nm 186.25
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20345147
Title Proline-containing cyclopeptides from the marine sponge Phakellia fusca
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18415
This work is licensed under a Creative Commons Attribution 4.0 International License.