Phakellistatin 17

General Information


DRACP ID  DRACP02921

Peptide Name   Phakellistatin 17

Sequence  PWVPLIPI

Sequence Length  8

UniProt ID  Not available

PubChem CID  46209787 

Origin  Phakellia fusca

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
P388 Mouse lymphoma Lymphoma Not active up to 100 µg/ml MTT assay 48 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02921

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Pro1<--->Ile8

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C49H75N9O9

Absent amino acids  ACDEFGHKMNQRSTY

Common amino acids  P

Mass  105923

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  5

Net charge  0

Boman Index  2113

Hydrophobicity  141.25

Aliphatic Index  182.5

Half Life 
  Mammalian: >20 hour
  Yeast: >20 hour
  E.coli: ?

Extinction Coefficient cystines  5500

Absorbance 280nm  785.71

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 20345147

Title  Proline-containing cyclopeptides from the marine sponge Phakellia fusca

Doi 10.1021/np9008267

Year  2010

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPN_18417

DRACP is developed by Dr.Zheng's team.