This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 18
General Information
DRACP ID DRACP02922
Peptide Name Phakellistatin 18
Sequence PYPIFPI
Sequence Length 7
UniProt ID Not available
PubChem CID 46886697
Origin Phakellia fusca
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| P388 | Mouse lymphoma | Lymphoma | Not active up to 100 µg/ml | MTT assay | 48 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=6.7 μM | SRB assay | Not available | 2 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=3.9 μM | SRB assay | Not available | 2 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=33 μM | SRB assay | Not available | 2 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=9.1 μM | SRB assay | Not available | 2 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50=7.7 μM | SRB assay | Not available | 2 |
| SNU-638 | Gastric adenocarcinoma | Carcinoma | IC50=37 μM | SRB assay | Not available | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Ile7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C45H63N7O9
Absent amino acids ACDEGHKLMNQRSTVW
Common amino acids P
Mass 95323
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 1268
Hydrophobicity 81.43
Aliphatic Index 111.43
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 1490
Absorbance 280nm 248.33
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20345147
Title Proline-containing cyclopeptides from the marine sponge Phakellia fusca
Year 2010
Literature 2
Pubmed ID 29893558
Title Cyclopeptides from the Sponge Stylissa flabelliformis
Doi 10.1021/acs.jnatprod.8b00121
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18418
This work is licensed under a Creative Commons Attribution 4.0 International License.