This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 19
General Information
DRACP ID DRACP02923
Peptide Name Phakellistatin 19
Sequence IPWFPLTP
Sequence Length 8
UniProt ID Not available
PubChem CID 57335467
Origin Phakellia fusca
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=0.44 µM | MTT assay | 8 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=0.462 µM | MTT assay | 8 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=0.515 µM | MTT assay | 8 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Ile1<--->Pro8
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C51H71N9O10
Absent amino acids ACDEGHKMNQRSVY
Common amino acids P
Mass 109521
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 4
Net charge 0
Boman Index 1258
Hydrophobicity 58.75
Aliphatic Index 97.5
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 5500
Absorbance 280nm 785.71
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24252114
Title Rescuing biological activity from synthetic phakellistatin 19
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18419
This work is licensed under a Creative Commons Attribution 4.0 International License.