Phakellistatin 19

General Information


DRACP ID  DRACP02923

Peptide Name   Phakellistatin 19

Sequence  IPWFPLTP

Sequence Length  8

UniProt ID  Not available

PubChem CID  57335467 

Origin  Phakellia fusca

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma IC50=0.44 µM MTT assay 8 h 1
HT-29 Colon adenocarcinoma Carcinoma IC50=0.462 µM MTT assay 8 h 1
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=0.515 µM MTT assay 8 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02923

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Ile1<--->Pro8

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C51H71N9O10

Absent amino acids  ACDEGHKMNQRSVY

Common amino acids  P

Mass  109521

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  4

Net charge  0

Boman Index  1258

Hydrophobicity  58.75

Aliphatic Index  97.5

Half Life 
  Mammalian: >20 hour
  Yeast: >20 hour
  E.coli: ?

Extinction Coefficient cystines  5500

Absorbance 280nm  785.71

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 24252114

Title  Rescuing biological activity from synthetic phakellistatin 19

Doi 10.1021/jm401520x

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPN_18419

DRACP is developed by Dr.Zheng's team.