This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 21
General Information
DRACP ID DRACP02925
Peptide Name Phakellistatin 21
Sequence PPXFELPPYI
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Stylissa flabelliformis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=0.19 µM | SRB assay | Not available | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=0.14 µM | SRB assay | Not available | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=0.17 µM | SRB assay | Not available | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=0.4 µM | SRB assay | Not available | 1 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50=0.041 µM | SRB assay | Not available | 1 |
| SNU-638 | Gastric adenocarcinoma | Carcinoma | IC50=0.16 µM | SRB assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Ile7
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Methionine sulfone
Chiral L
Physicochemical Information
Formula C55H75N9O12
Absent amino acids ACDGHKMNQRSTVW
Common amino acids P
Mass 132495
Pl 3.85
Basic residues 0
Acidic residues 1
Hydrophobic residues 3
Net charge -1
Boman Index 587
Hydrophobicity -1
Aliphatic Index 78
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29893558
Title Cyclopeptides from the Sponge Stylissa flabelliformis
Doi 10.1021/acs.jnatprod.8b00121
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18422
This work is licensed under a Creative Commons Attribution 4.0 International License.