This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 2
General Information
DRACP ID DRACP02927
Peptide Name Phakellistatin 2
Sequence IxPYPFP
Sequence Length 7
UniProt ID Not available
PubChem CID 101663073
Origin Stylotella aurantium
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A2780 | Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary | Carcinoma | IC50=28.27 µg/ml (DMSO); IC50=2.72 µg/ml (MeOH) | SRB assay | Not available | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=0.66 µM | SRB assay | Not available | 2 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=0.71 µM | SRB assay | Not available | 2 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=3.2 µM | SRB assay | Not available | 2 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=1.3 µM | SRB assay | Not available | 2 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50=0.77 µM | SRB assay | Not available | 2 |
| SNU-638 | Gastric adenocarcinoma | Carcinoma | IC50=1.6 µM | SRB assay | Not available | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Ile1<--->Pro7
N-terminal Modification Free
C-terminal Modification Free
Other Modification x=D-Allo-Ile
Chiral Mix
Physicochemical Information
Formula C39H50N6O7
Absent amino acids ACDEGHKLMNQRSTVW
Common amino acids P
Mass 82205
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 2
Net charge 0
Boman Index 776
Hydrophobicity 17.14
Aliphatic Index 55.71
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 248.33
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12444643
Title Two distinct conformers of the cyclic heptapeptide phakellistatin 2 isolated from the fijian marine sponge stylotellaaurantium
Year 2002
Literature 2
Pubmed ID 29893558
Title Cyclopeptides from the Sponge Stylissa flabelliformis
Doi 10.1021/acs.jnatprod.8b00121
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18423
This work is licensed under a Creative Commons Attribution 4.0 International License.