This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 4
General Information
DRACP ID DRACP02928
Peptide Name Phakellistatin 4
Sequence PtPfiFS
Sequence Length 7
UniProt ID Not available
PubChem CID 101917675
Origin Phakellia costata
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=7.4 µM | SRB assay | Not available | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=4.5 µM | SRB assay | Not available | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=30 µM | SRB assay | Not available | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=10 µM | SRB assay | Not available | 1 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50=7.2 µM | SRB assay | Not available | 1 |
| SNU-638 | Gastric adenocarcinoma | Carcinoma | IC50=24 µM | SRB assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Ser7
N-terminal Modification Free
C-terminal Modification Free
Other Modification t=D-Thr; f=D-Phe; i=D-Ile
Chiral Mix
Physicochemical Information
Formula C22H24N4O3
Absent amino acids ACDEGHIKLMNQRTVWY
Common amino acids P
Mass 49964
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 1
Net charge 0
Boman Index -42
Hydrophobicity -17.14
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29893558
Title Cyclopeptides from the Sponge Stylissa flabelliformis
Doi 10.1021/acs.jnatprod.8b00121
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18424
This work is licensed under a Creative Commons Attribution 4.0 International License.