This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 11
General Information
DRACP ID DRACP02930
Peptide Name Phakellistatin 11
Sequence QPFPfifp
Sequence Length 8
UniProt ID Not available
PubChem CID 101927059
Origin Phakellia sp.
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=2.8 µM | SRB assay | Not available | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=1.6 µM | SRB assay | Not available | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=5.6 µM | SRB assay | Not available | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=3.2 µM | SRB assay | Not available | 1 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50=1.7 µM | SRB assay | Not available | 1 |
| SNU-638 | Gastric adenocarcinoma | Carcinoma | IC50=6.9 µM | SRB assay | Not available | 1 |
| P388 | Mouse lymphoma | Lymphoma | ED50=0.2 µg/ml | Not available | Not available | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Gln1<--->pro10
N-terminal Modification Free
C-terminal Modification Free
Other Modification f=D-Phe; i=D-Ile
Chiral Mix
Physicochemical Information
Formula C24H25N5O2
Absent amino acids ACDEGHIKLMNRSTVWY
Common amino acids P
Mass 54052
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 1
Net charge 0
Boman Index -256
Hydrophobicity -48.75
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29893558
Title Cyclopeptides from the Sponge Stylissa flabelliformis
Doi 10.1021/acs.jnatprod.8b00121
Year 2018
Literature 2
Pubmed ID 7673945
Title Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from Phakellia sp
Year 1995
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18426
This work is licensed under a Creative Commons Attribution 4.0 International License.