This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 8
General Information
DRACP ID DRACP02931
Peptide Name Phakellistatin 8
Sequence IFVLPPYIPP
Sequence Length 10
UniProt ID Not available
PubChem CID 10102761
Origin Phakellia fusca
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=0.54 µM | SRB assay | Not available | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=0.1 µM | SRB assay | Not available | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=0.29 µM | SRB assay | Not available | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=2.5 µM | SRB assay | Not available | 1 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50=2.3 µM | SRB assay | Not available | 1 |
| SNU-638 | Gastric adenocarcinoma | Carcinoma | IC50=1.7 µM | SRB assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Ile1<--->Pro10
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C61H90N10O12
Absent amino acids ACDEGHKMNQRSTW
Common amino acids P
Mass 131615
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 5
Net charge 0
Boman Index 2164
Hydrophobicity 121
Aliphatic Index 146
Half Life
Mammalian: 0.8 hour
Yeast: 10 min
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29893558
Title Cyclopeptides from the Sponge Stylissa flabelliformis
Doi 10.1021/acs.jnatprod.8b00121
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18420
This work is licensed under a Creative Commons Attribution 4.0 International License.