This work is licensed under a Creative Commons Attribution 4.0 International License.
Hymenamide D
General Information
DRACP ID DRACP02932
Peptide Name Hymenamide D
Sequence aIpyDPL
Sequence Length 7
UniProt ID Not available
PubChem CID 146001396
Origin Hymeniacidon sp.
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50>50 µM | SRB assay | Not available | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| SNU-638 | Gastric adenocarcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>50 µM | MTT assay | 3 days | 2 |
| RAW 264.7 | Mouse leukemia | Leukemia | IC50>50 µM | MTT assay | 3 days | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: ala1<--->Leu7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral Mix
Physicochemical Information
Formula C21H30N4O4
Absent amino acids ACEFGHKMNQRSTVWY
Common amino acids DILP
Mass 50970
Pl 3.75
Basic residues 0
Acidic residues 1
Hydrophobic residues 2
Net charge -1
Boman Index 112
Hydrophobicity 45.71
Aliphatic Index 111.43
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29893558
Title Cyclopeptides from the Sponge Stylissa flabelliformis
Doi 10.1021/acs.jnatprod.8b00121
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18427
This work is licensed under a Creative Commons Attribution 4.0 International License.