This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclonellin
General Information
DRACP ID DRACP02933
Peptide Name Cyclonellin
Sequence ANPRYPYT
Sequence Length 8
UniProt ID Not available
PubChem CID 21576266
Origin Axinella carteri
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50>50 µM | SRB assay | Not available | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| SNU-638 | Gastric adenocarcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Ala1<--->Thr8
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C45H64N12O13
Absent amino acids CDEFGHIKLMQSVW
Common amino acids PY
Mass 110610
Pl 9.17
Basic residues 1
Acidic residues 0
Hydrophobic residues 1
Net charge 1
Boman Index -2260
Hydrophobicity -158.75
Aliphatic Index 12.5
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 2980
Absorbance 280nm 425.71
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29893558
Title Cyclopeptides from the Sponge Stylissa flabelliformis
Doi 10.1021/acs.jnatprod.8b00121
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18428
This work is licensed under a Creative Commons Attribution 4.0 International License.