Carteritin A

General Information


DRACP ID  DRACP02934

Peptide Name   Carteritin A

Sequence  ANPRYPYT

Sequence Length  8

UniProt ID  Not available

PubChem CID  132516354 

Origin  Stylissa carteri

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma IC50=19 µM SRB assay Not available 1
HCT 116 Colon carcinoma Carcinoma IC50=6.2 µM SRB assay Not available 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia Leukemia IC50=3.9 µM SRB assay Not available 1
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=17 µM SRB assay Not available 1
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Carcinoma IC50=11 µM SRB assay Not available 1
SNU-638 Gastric adenocarcinoma Carcinoma IC50=11 µM SRB assay Not available 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=1.3 µM MTT assay 3 days 2
RAW 264.7 Mouse leukemia Leukemia IC50=1.5 µM MTT assay 3 days 2

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02934

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Glu1<--->Pro7

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C45H64N12O13

Absent amino acids  CDEFGHIKLMQSVW

Common amino acids  PY

Mass  110610

Pl  9.17

Basic residues  1

Acidic residues  0

Hydrophobic residues  1

Net charge  1

Boman Index  -2260

Hydrophobicity  -158.75

Aliphatic Index  12.5

Half Life 
  Mammalian: 4.4 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  2980

Absorbance 280nm  425.71

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29893558

Title  Cyclopeptides from the Sponge Stylissa flabelliformis

Doi 10.1021/acs.jnatprod.8b00121

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPN_18429

DRACP is developed by Dr.Zheng's team.