This work is licensed under a Creative Commons Attribution 4.0 International License.
Carteritin B
General Information
DRACP ID DRACP02935
Peptide Name Carteritin B
Sequence LYPYYPS
Sequence Length 7
UniProt ID Not available
PubChem CID 132516355
Origin Stylissa carteri
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50>50 µM | SRB assay | Not available | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| SNU-638 | Gastric adenocarcinoma | Carcinoma | IC50>50 µM | SRB assay | Not available | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>50 µM | MTT assay | 3 days | 2 |
| RAW 264.7 | Mouse leukemia | Leukemia | IC50>50 µM | MTT assay | 3 days | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Leu1<--->Ser7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C46H59N7O12
Absent amino acids ACDEFGHIKMNQRTVW
Common amino acids Y
Mass 100920
Pl 6.08
Basic residues 0
Acidic residues 0
Hydrophobic residues 1
Net charge 0
Boman Index 110
Hydrophobicity -58.57
Aliphatic Index 55.71
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 4470
Absorbance 280nm 745
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29893558
Title Cyclopeptides from the Sponge Stylissa flabelliformis
Doi 10.1021/acs.jnatprod.8b00121
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18430
This work is licensed under a Creative Commons Attribution 4.0 International License.