This work is licensed under a Creative Commons Attribution 4.0 International License.
Hymenamide C
General Information
DRACP ID DRACP02936
Peptide Name Hymenamide C
Sequence ELWPFGP
Sequence Length 7
UniProt ID Not available
PubChem CID 145740401
Origin Hymeniacidon sp.
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=25 µM | MTT assay | 3 days | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=5 µM | MTT assay | 3 days | 1 |
| RAW 264.7 | Mouse leukemia | Leukemia | IC50>50 µM | MTT assay | 3 days | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Glu1<--->Pro7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C43H56N8O10
Absent amino acids ACDHIKMNQRSTVY
Common amino acids P
Mass 95216
Pl 3.85
Basic residues 0
Acidic residues 1
Hydrophobic residues 3
Net charge -1
Boman Index 436
Hydrophobicity -20
Aliphatic Index 55.71
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 916.67
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Carteritins A and B, cyclic heptapeptides from the marine sponge Stylissa carteri
Doi 10.1016/j.tetlet.2016.02.031
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPN_18431
This work is licensed under a Creative Commons Attribution 4.0 International License.