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Phakellistatin 13
General Information
DRACP ID DRACP02937
Peptide Name Phakellistatin 13
Sequence GPTLWPF
Sequence Length 7
UniProt ID Not available
PubChem CID 11125657
Origin Phakellia fusca
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50 = 17 μg/mL | Not available | Not available | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=15 µM | MTT assay | 3 days | 2 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50>50 µM | MTT assay | 3 days | 2 |
| RAW 264.7 | Mouse leukemia | Leukemia | IC50>50 µM | MTT assay | 3 days | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Gly1<--->Phe7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C42H56N8O9
Absent amino acids ACDEHIKMNQRSVY
Common amino acids P
Mass 92415
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 860
Hydrophobicity 20
Aliphatic Index 55.71
Half Life
Mammalian: 1 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 916.67
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12542366
Title Isolation and structure of the cytotoxic cycloheptapeptide phakellistatin 13
Year 2003
Literature 2
Pubmed ID Not available
Title Carteritins A and B, cyclic heptapeptides from the marine sponge Stylissa carteri
Doi 10.1016/j.tetlet.2016.02.031
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.