This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 10
General Information
DRACP ID DRACP02938
Peptide Name Phakellistatin 10
Sequence IPYVPLTP
Sequence Length 8
UniProt ID Not available
PubChem CID 44584154
Origin Phakellia sp.
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| P388 | Mouse lymphoma | Lymphoma | ED50=2.1 µg/ml | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Glu1<--->Pro8
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C45H70N8O11
Absent amino acids ACDEFGHKMNQRSW
Common amino acids P
Mass 102413
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 1117
Hydrophobicity 71.25
Aliphatic Index 133.75
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 212.86
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 7673945
Title Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from Phakellia sp
Year 1995
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.