This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 5
General Information
DRACP ID DRACP02939
Peptide Name Phakellistatin 5
Sequence AIPFNAM
Sequence Length 7
UniProt ID Not available
PubChem CID 11115315
Origin Phakellia costada
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| P388 | Mouse lymphoma | Lymphoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| OVCAR-3 | High grade ovarian serous adenocarcinoma | Carcinoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| SF295 | Glioblastoma | Blastoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| NCI-H460 | Lung large cell carcinoma | Carcinoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| DU145 | Prostate carcinoma | Carcinoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| KM20L2 | Colon adenocarcinoma | Carcinoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| SK-MEL-5 | Cutaneous melanoma | Carcinoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Ala1<--->Met7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C35H54N8O9S
Absent amino acids CDEGHKLQRSTVWY
Common amino acids A
Mass 87013
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 4
Net charge 0
Boman Index 723
Hydrophobicity 110
Aliphatic Index 84.29
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10650072
Title Synthesis of the marine sponge cycloheptapeptide phakellistatin 5(1)
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.