This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 1
General Information
DRACP ID DRACP02940
Peptide Name Phakellistatin 1
Sequence PIPIFPY
Sequence Length 7
UniProt ID Not available
PubChem CID 11765991
Origin Phakellia costata; Stylotella aurantium
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| P388 | Mouse lymphoma | Lymphoma | ED50=7.5 μg/mL | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Tyr7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C45H63N7O9
Absent amino acids ACDEGHKLMNQRSTVW
Common amino acids P
Mass 95323
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 1268
Hydrophobicity 81.43
Aliphatic Index 111.43
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 248.33
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28335479
Title Phakellistatins: An Underwater Unsolved Puzzle
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.