This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 7
General Information
DRACP ID DRACP02943
Peptide Name Phakellistatin 7
Sequence PPIFALPPYI
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Phakellia costata
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| P388 | Mouse lymphoma | Lymphoma | ED50=3.2 μg/mL | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Ile10
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C59H86N10O12
Absent amino acids CDEGHKMNQRSTVW
Common amino acids P
Mass 128810
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 5
Net charge 0
Boman Index 1941
Hydrophobicity 97
Aliphatic Index 127
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28335479
Title Phakellistatins: An Underwater Unsolved Puzzle
Year 2017
Literature 2
Pubmed ID Not available
Title Synthesis, structure, and biological aspects of cyclopeptides related to marine phakellistatins 7–9
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.