This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 12
General Information
DRACP ID DRACP02944
Peptide Name Phakellistatin 12
Sequence PPIFTLPPYI
Sequence Length 10
UniProt ID Not available
PubChem CID 21578711
Origin Phakellia sp.
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| P388 | Mouse lymphoma | Lymphoma | ED50=2.8 μg/mL | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Pro1<--->Ile10
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C60H88N10O13
Absent amino acids ACDEGHKMNQRSVW
Common amino acids P
Mass 131812
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 4
Net charge 0
Boman Index 1503
Hydrophobicity 72
Aliphatic Index 117
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12639558
Title Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a Chuuk archipelago marine sponge
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.