Peptide Libraray

Diketopiperazine (preWA)

General Information

DRACP ID DRACP02955

Peptide Name Diketopiperazine (preWA)

Sequence XA

Sequence Length 2

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
K562	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia	Leukemia	IC50=35.2 μM	MTT assay	72 h	1
A2780	Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary	Carcinoma	IC50=89.8 μM	MTT assay	72 h	1
A2780-cisR	Ovarian endometrioid adenocarcinoma	Carcinoma	IC50=82.2 μM	MTT assay	72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: X1<--->Ala2

N-terminal Modification Free

C-terminal Modification Free

Other Modification X=Prenylated-Trp

Chiral L

Physicochemical Information

Formula C3H5NO

Absent amino acids CDEFGHIKLMNPQRSTVWY

Common amino acids AX

Mass 19910

Pl 6.11

Basic residues 0

Acidic residues 0

Hydrophobic residues 1

Net charge 0

Boman Index 181

Hydrophobicity 90

Aliphatic Index 50

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22617493

Title Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides

Doi 10.1016/j.bmcl.2012.04.119

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_18866