This work is licensed under a Creative Commons Attribution 4.0 International License.
Diketopiperazine (prewA)
General Information
DRACP ID DRACP02958
Peptide Name Diketopiperazine (prewA)
Sequence XA
Sequence Length 2
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=35.3 μM | MTT assay | 72 h | 1 |
| A2780 | Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary | Carcinoma | IC50=86.2 μM | MTT assay | 72 h | 1 |
| A2780-cisR | Ovarian endometrioid adenocarcinoma | Carcinoma | IC50=84.3 μM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: X1<--->Ala2
N-terminal Modification Free
C-terminal Modification Free
Other Modification x=Prenylated-D-Trp
Chiral L
Physicochemical Information
Formula C3H5NO
Absent amino acids CDEFGHIKLMNPQRSTVWY
Common amino acids AX
Mass 19910
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 1
Net charge 0
Boman Index 181
Hydrophobicity 90
Aliphatic Index 50
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22617493
Title Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
Doi 10.1016/j.bmcl.2012.04.119
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.