Diketopiperazine (prewA)

General Information


DRACP ID  DRACP02958

Peptide Name   Diketopiperazine (prewA)

Sequence  XA

Sequence Length  2

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
K562 Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia Leukemia IC50=35.3 μM MTT assay 72 h 1
A2780 Ovarian endometrioid adenocarcinoma; Endometrioid carcinoma of ovary Carcinoma IC50=86.2 μM MTT assay 72 h 1
A2780-cisR Ovarian endometrioid adenocarcinoma Carcinoma IC50=84.3 μM MTT assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: X1<--->Ala2

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  x=Prenylated-D-Trp

Chiral  L



Physicochemical Information


Formula  C3H5NO

Absent amino acids  CDEFGHIKLMNPQRSTVWY

Common amino acids  AX

Mass  19910

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  1

Net charge  0

Boman Index  181

Hydrophobicity  90

Aliphatic Index  50

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 22617493

Title  Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides

Doi 10.1016/j.bmcl.2012.04.119

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.