Peptide Libraray

Diketopiperazine (GI)

General Information

DRACP ID DRACP02961

Peptide Name Diketopiperazine (GI)

Sequence GI

Sequence Length 2

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	21.33 ± 1.83% Inhibition=10 µM ; 28.45 ± 2.05% Inhibition=100 µM	MTT assay	48 h	1
HT-29	Colon adenocarcinoma	Carcinoma	8.62 ± 0.78% Inhibition=10 µM; 26.74 ± 1.38% Inhibition=100 µM	MTT assay	48 h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	12.56 ± 1.03% Inhibition=10 µM; 23.58 ± 1.70% Inhibition=100 µM	MTT assay	48 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure DRACP02961

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Gly1<--->Ile2

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C8H16N2O3

Absent amino acids ACDEFHKLMNPQRSTVWY

Common amino acids GI

Mass 20625

Pl 6.11

Basic residues 0

Acidic residues 0

Hydrophobic residues 1

Net charge 0

Boman Index 586

Hydrophobicity 205

Aliphatic Index 195

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 18436344

Title The synthesis and anticancer activity of selected diketopiperazines

Doi 10.1016/j.peptides.2008.03.010

Year 2008

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available