Peptide Libraray

Diketopiperazine (GV)

General Information

DRACP ID DRACP02962

Peptide Name Diketopiperazine (GV)

Sequence GV

Sequence Length 2

UniProt ID Not available

PubChem CID 736942

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	12.58 ± 1.23% Inhibition=10 µM ; 23.46 ± 2.04% Inhibition=100 µM	MTT assay	48 h	1
HT-29	Colon adenocarcinoma	Carcinoma	6.87 ± 0.67% Inhibition=10 µM; 23.90 ± 2.25% Inhibition=100 µM	MTT assay	48 h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	7.00 ± 0.56% Inhibition=10 µM; 21.19 ± 2.04% Inhibition=100 µM	MTT assay	48 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure DRACP02962

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Gly1<--->Val2

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C7H14N2O3

Absent amino acids ACDEFHIKLMNPQRSTWY

Common amino acids GV

Mass 19222

Pl 6.11

Basic residues 0

Acidic residues 0

Hydrophobic residues 1

Net charge 0

Boman Index 498

Hydrophobicity 190

Aliphatic Index 145

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 18436344

Title The synthesis and anticancer activity of selected diketopiperazines

Doi 10.1016/j.peptides.2008.03.010

Year 2008

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_18854