This work is licensed under a Creative Commons Attribution 4.0 International License.
Diketopiperazine (Gv)
General Information
DRACP ID DRACP02963
Peptide Name Diketopiperazine (Gv)
Sequence Gv
Sequence Length 2
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 19.61 ± 0.82% Inhibition=10 µM ; 20.55 ± 2.03% Inhibition=100 µM | MTT assay | 48 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | 14.29 ± 1.40% Inhibition=10 µM; 16.78 ± 1.65% Inhibition=100 µM | MTT assay | 48 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | 19.78 ± 1.86% Inhibition=10 µM; 21.94 ± 2.17% Inhibition=100 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Gly1<--->val2
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral Mix
Physicochemical Information
Formula C2H3NO
Absent amino acids ACDEFHIKLMNPQRSTVWY
Common amino acids G
Mass 7507
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 0
Net charge 0
Boman Index 94
Hydrophobicity -20
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18436344
Title The synthesis and anticancer activity of selected diketopiperazines
Doi 10.1016/j.peptides.2008.03.010
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.