Diketopiperazine (GC)

General Information


DRACP ID  DRACP02964

Peptide Name   Diketopiperazine (GC)

Sequence  GC

Sequence Length  2

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma 43.92 ± 0.02% Inhibition=10 µM ; 57.79 ± 0.02% Inhibition=100 µM MTT assay 48 h 1
HT-29 Colon adenocarcinoma Carcinoma 30.56 ± 0.03% Inhibition=10 µM; 51.29 ± 0.01% Inhibition=100 µM MTT assay 48 h 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma 36.49 ± 0.02% Inhibition=10 µM; 56.08 ± 0.01% Inhibition=100 µM MTT assay 48 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP02964

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Gly1<--->Cys2

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C5H10N2O3S

Absent amino acids  ADEFHIKLMNPQRSTVWY

Common amino acids  CG

Mass  19623

Pl  5.92

Basic residues  0

Acidic residues  0

Hydrophobic residues  0

Net charge  0

Boman Index  222

Hydrophobicity  105

Aliphatic Index  0

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 18436344

Title  The synthesis and anticancer activity of selected diketopiperazines

Doi 10.1016/j.peptides.2008.03.010

Year  2008

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.