Peptide Libraray

Diketopiperazine (GC)

General Information

DRACP ID DRACP02964

Peptide Name Diketopiperazine (GC)

Sequence GC

Sequence Length 2

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	43.92 ± 0.02% Inhibition=10 µM ; 57.79 ± 0.02% Inhibition=100 µM	MTT assay	48 h	1
HT-29	Colon adenocarcinoma	Carcinoma	30.56 ± 0.03% Inhibition=10 µM; 51.29 ± 0.01% Inhibition=100 µM	MTT assay	48 h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	36.49 ± 0.02% Inhibition=10 µM; 56.08 ± 0.01% Inhibition=100 µM	MTT assay	48 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure DRACP02964

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Gly1<--->Cys2

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C5H10N2O3S

Absent amino acids ADEFHIKLMNPQRSTVWY

Common amino acids CG

Mass 19623

Pl 5.92

Basic residues 0

Acidic residues 0

Hydrophobic residues 0

Net charge 0

Boman Index 222

Hydrophobicity 105

Aliphatic Index 0

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 18436344

Title The synthesis and anticancer activity of selected diketopiperazines

Doi 10.1016/j.peptides.2008.03.010

Year 2008

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available