Oncocin Onc112 [K3R], Onc246

General Information


DRACP ID  DRACP02967

Peptide Name   Oncocin Onc112 [K3R], Onc246

Sequence  VDRPPYLPRPRPPRrIYNr

Sequence Length  19

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma 46% Killing=600 µg/ml MTT assay 20 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HEK293: 42% Killing=600 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  Mix



Physicochemical Information


Formula  C97H148N30O21

Absent amino acids  ACEFGHKMQSTW

Common amino acids  P

Mass  239164

Pl  11.14

Basic residues  4

Acidic residues  1

Hydrophobic residues  3

Net charge  3

Boman Index  -6144

Hydrophobicity  -130

Aliphatic Index  56.32

Half Life 
  /

Extinction Coefficient cystines  2980

Absorbance 280nm  165.56

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 34902208

Title  Effect of Amino Acid Substitutions on 70S Ribosomal Binding, Cellular Uptake, and Antimicrobial Activity of Oncocin Onc112

Doi Effect of Amino Acid Substitutions on 70S Ribosomal Binding, Cellular Uptake, and Antimicrobial Activity of Oncocin Onc112

Year  2022

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_18876

DRACP is developed by Dr.Zheng's team.