Cyclopeptide GG-8-6 [L9A]

General Information


DRACP ID  DRACP03013

Peptide Name   Cyclopeptide GG-8-6 [L9A]

Sequence  VLPILLLVA

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Induce apoptosis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
SMMC-7721 Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=38.92 μM MTT assay 24 h 1
HepG2 Hepatoblastoma Blastoma IC50=38.64 μM MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP03013

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Val1<--->Ala9

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C48H87N9O10

Absent amino acids  CDEFGHKMNQRSTWY

Common amino acids  L

Mass  109317

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  8

Net charge  0

Boman Index  3449

Hydrophobicity  314.44

Aliphatic Index  292.22

Half Life 
  Mammalian: 100 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29310863

Title  Synthesis and biological evaluation of cyclopeptide GG-8-6 and its analogues as anti-hepatocellular carcinoma agents

Doi 10.1016/j.bmc.2017.12.028

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_20097

DRACP is developed by Dr.Zheng's team.