This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclopeptide GG-8-6 (1-6)
General Information
DRACP ID DRACP03023
Peptide Name Cyclopeptide GG-8-6 (1-6)
Sequence VLPILL
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SMMC-7721 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>100 μM | MTT assay | 24 h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | IC50>100 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Val1<--->Leu6
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C34H62N6O7
Absent amino acids ACDEFGHKMNQRSTWY
Common amino acids L
Mass 75628
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 5
Net charge 0
Boman Index 2372
Hydrophobicity 308.33
Aliphatic Index 308.33
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29310863
Title Synthesis and biological evaluation of cyclopeptide GG-8-6 and its analogues as anti-hepatocellular carcinoma agents
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_20107
This work is licensed under a Creative Commons Attribution 4.0 International License.