This work is licensed under a Creative Commons Attribution 4.0 International License.
Puma-BH3
General Information
DRACP ID DRACP03025
Peptide Name Puma-BH3
Sequence EQWAREIGAQLRRMADDLNA
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bcl-xL inhibitors BH3 peptides and mimetics
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 (Bc1-xL dependent) | Breast adenocarcinoma | Carcinoma | EC50=1.006 ± 0.337 μM | Not available | Not available | 1 |
| OCI-Ly1 (Bcl-2 dependent) | Diffuse large B-cell lymphoma | Lymphoma | EC50=1.967 ± 0.48 μM | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-xL
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C98H159N33O32S
Absent amino acids CFHKPSTVY
Common amino acids A
Mass 268271
Pl 4.54
Basic residues 3
Acidic residues 4
Hydrophobic residues 8
Net charge -1
Boman Index -6592
Hydrophobicity -90.5
Aliphatic Index 78.5
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 289.47
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25451027
Title Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.