This work is licensed under a Creative Commons Attribution 4.0 International License.
XXA4-BH3
General Information
DRACP ID DRACP03027
Peptide Name XXA4-BH3
Sequence RPEIWYAQWLKRFGDQFNAYYAR
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bcl-xL inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-xL
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C142H196N38O34
Absent amino acids CHMSTV
Common amino acids ARY
Mass 337194
Pl 9.78
Basic residues 4
Acidic residues 2
Hydrophobic residues 9
Net charge 2
Boman Index -5715
Hydrophobicity -101.3
Aliphatic Index 46.96
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 15470
Absorbance 280nm 703.18
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25451027
Title Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.