This work is licensed under a Creative Commons Attribution 4.0 International License.
BimEL I146Y-I153M
General Information
DRACP ID DRACP03040
Peptide Name BimEL I146Y-I153M
Sequence LRPEIRYAQELRRMGDEFNE
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bcl-xL/Bac-2 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-2/Bcl-xL
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C108H172N34O34S
Absent amino acids CHKSTVW
Common amino acids ER
Mass 286189
Pl 4.71
Basic residues 4
Acidic residues 5
Hydrophobic residues 5
Net charge -1
Boman Index -8512
Hydrophobicity -136
Aliphatic Index 63.5
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 78.42
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30860026
Title Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.